Loss of Selenium-Binding Protein 1 Decreases Sensitivity to Clastogens and Intracellular Selenium Content in HeLa Cells

Selenium-binding protein 1 (SBP1) is not a selenoprotein but structurally binds selenium. Loss of SBP1 during carcinogenesis usually predicts poor prognosis. Because genome instability is a hallmark of cancer, we hypothesize that SBP1 sequesters cellular selenium and sensitizes cancer cells to DNA-d...

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Detalles Bibliográficos
Autores principales: Zhao, Changhui, Zeng, Huawei, Wu, Ryan T. Y., Cheng, Wen-Hsing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942091/
https://www.ncbi.nlm.nih.gov/pubmed/27404728
http://dx.doi.org/10.1371/journal.pone.0158650

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942091/
https://www.ncbi.nlm.nih.gov/pubmed/27404728
http://dx.doi.org/10.1371/journal.pone.0158650

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