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Structures of Gate Loop Variants of the AcrB Drug Efflux Pump Bound by Erythromycin Substrate
Gram-negative bacteria such as E. coli use tripartite efflux pumps such as AcrAB-TolC to expel antibiotics and noxious compounds. A key feature of the inner membrane transporter component, AcrB, is a short stretch of residues known as the gate/switch loop that divides the proximal and distal substra...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942123/ https://www.ncbi.nlm.nih.gov/pubmed/27403665 http://dx.doi.org/10.1371/journal.pone.0159154 |