FG-3019, a Human Monoclonal Antibody Recognizing Connective Tissue Growth Factor, is Subject to Target-Mediated Drug Disposition

PURPOSE: To evaluate and model the pharmacokinetic and pharmacodynamic behavior in rats of FG-3019, a human monoclonal antibody targeting connective tissue growth factor (CTGF). METHODS: FG-3019, human CTGF (rhCTGF), or the N-terminal domain of rhCTGF were administered intravenously to rats and conc...

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Detalles Bibliográficos
Autores principales: Brenner, Mitchell C., Krzyzanski, Wojciech, Chou, James Z., Signore, Pierre E., Fung, Cyra K., Guzman, David, Li, Dongxia, Zhang, Weihua, Olsen, David R., Nguyen, Viet-Tam L., Koo, Carolyn W., Sternlicht, Mark D., Lipson, Kenneth E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942499/
https://www.ncbi.nlm.nih.gov/pubmed/27059922
http://dx.doi.org/10.1007/s11095-016-1918-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942499/
https://www.ncbi.nlm.nih.gov/pubmed/27059922
http://dx.doi.org/10.1007/s11095-016-1918-0

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