CHIP(−/−)-Mouse Liver: Adiponectin-AMPK-FOXO-Activation Overrides CYP2E1-Elicited JNK1-Activation, Delaying Onset of NASH: Therapeutic Implications

Genetic ablation of C-terminus of Hsc70-interacting protein (CHIP) E3 ubiquitin-ligase impairs hepatic cytochrome P450 CYP2E1 degradation. Consequent CYP2E1 gain of function accelerates reactive O(2) species (ROS) production, triggering oxidative/proteotoxic stress associated with sustained activati...

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Detalles Bibliográficos
Autores principales: Kim, Sung-Mi, Grenert, James P., Patterson, Cam, Correia, Maria Almira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942616/
https://www.ncbi.nlm.nih.gov/pubmed/27406999
http://dx.doi.org/10.1038/srep29423

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942616/
https://www.ncbi.nlm.nih.gov/pubmed/27406999
http://dx.doi.org/10.1038/srep29423

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