Exploring the induction of preproinsulin-specific Foxp3(+) CD4(+) Treg cells that inhibit CD8(+) T cell-mediated autoimmune diabetes by DNA vaccination

DNA vaccination is a promising strategy to induce effector T cells but also regulatory Foxp3(+) CD25(+) CD4(+) Treg cells and inhibit autoimmune disorders such as type 1 diabetes. Little is known about the antigen requirements that facilitate priming of Treg cells but not autoreactive effector CD8(+...

Descripción completa

Detalles Bibliográficos
Autores principales: Stifter, Katja, Schuster, Cornelia, Schlosser, Michael, Boehm, Bernhard Otto, Schirmbeck, Reinhold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942695/
https://www.ncbi.nlm.nih.gov/pubmed/27406624
http://dx.doi.org/10.1038/srep29419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942695/
https://www.ncbi.nlm.nih.gov/pubmed/27406624
http://dx.doi.org/10.1038/srep29419

Ejemplares similares