Cargando…

Exploring the induction of preproinsulin-specific Foxp3(+) CD4(+) Treg cells that inhibit CD8(+) T cell-mediated autoimmune diabetes by DNA vaccination

DNA vaccination is a promising strategy to induce effector T cells but also regulatory Foxp3(+) CD25(+) CD4(+) Treg cells and inhibit autoimmune disorders such as type 1 diabetes. Little is known about the antigen requirements that facilitate priming of Treg cells but not autoreactive effector CD8(+...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stifter, Katja, Schuster, Cornelia, Schlosser, Michael, Boehm, Bernhard Otto, Schirmbeck, Reinhold
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942695/ https://www.ncbi.nlm.nih.gov/pubmed/27406624 http://dx.doi.org/10.1038/srep29419

Ejemplares similares

A Missing PD-L1/PD-1 Coinhibition Regulates Diabetes Induction by Preproinsulin-Specific CD8 T-Cells in an Epitope-Specific Manner
por: Schuster, Cornelia, et al.
Publicado: (2013)

Preproinsulin Designer Antigens Excluded from Endoplasmic Reticulum Suppressed Diabetes Development in NOD Mice by DNA Vaccination
por: Stifter, Katja, et al.
Publicado: (2018)

A dominant insulin-specific and islet-destructive T-cell response is sufficient to activate CD8 T cells directed against the fatty-acid receptor GPR40
por: Spyrantis, Andreas, et al.
Publicado: (2019)

Deficiency in B7-H1 (PD-L1)/PD-1 Coinhibition Triggers Pancreatic β-Cell Destruction by Insulin-Specific, Murine CD8 T-Cells
por: Rajasalu, Tarvo, et al.
Publicado: (2010)

Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity
por: Ferreira, Ricardo C., et al.
Publicado: (2017)

Higher Sensitivity of Foxp3(+) Treg Compared to Foxp3(-) Conventional T Cells to TCR-Independent Signals for CD69 Induction
por: Bremser, Anna, et al.
Publicado: (2015)

Hepatitis B envelope antigen increases Tregs by converting CD4+CD25(-) T cells into CD4(+)CD25(+)Foxp3(+) Tregs
por: Tang, Rui, et al.
Publicado: (2020)

Endogenously Expressed Antigens Bind Mammalian RNA via Cationic Domains that Enhance Priming of Effector CD8 T Cells by DNA Vaccination
por: Krieger, Jana, et al.
Publicado: (2019)

FOXP3(+) Treg Cells and Gender Bias in Autoimmune Diseases
por: Nie, Jia, et al.
Publicado: (2015)

Changes in Natural Foxp3(+)Treg but Not Mucosally-Imprinted CD62L(neg)CD38(+)Foxp3(+)Treg in the Circulation of Celiac Disease Patients
por: van Leeuwen, Marieke A., et al.
Publicado: (2013)

Endometriotic Peritoneal Fluid Stimulates Recruitment of CD4(+)CD25(high)FOXP3(+) Treg Cells
por: Olkowska-Truchanowicz, Joanna, et al.
Publicado: (2021)

Induction of Foxp3 and activation of Tregs by HSP gp96 for treatment of autoimmune diseases
por: Xu, Yuxiu, et al.
Publicado: (2021)

CD8 T cell-mediated depletion of HBV surface-antigen-expressing, bilineal-differentiated liver carcinoma cells generates highly aggressive escape variants
por: Qiu, Na, et al.
Publicado: (2023)

The healthy exocrine pancreas contains preproinsulin-specific CD8 T cells that attack islets in type 1 diabetes
por: Bender, Christine, et al.
Publicado: (2020)

CD80 on Human T Cells Is Associated With FoxP3 Expression and Supports Treg Homeostasis
por: Soskic, Blagoje, et al.
Publicado: (2021)

IFN-γ treatment protocol for MHC-I(lo)/PD-L1(+) pancreatic tumor cells selectively restores their TAP-mediated presentation competence and CD8 T-cell priming potential
por: Stifter, Katja, et al.
Publicado: (2020)

Helios but not CD226, TIGIT and Foxp3 is a Potential Marker for CD4(+) Treg Cells in Patients with Rheumatoid Arthritis
por: Yang, Mengru, et al.
Publicado: (2019)

Asiaticoside ameliorates renal ischemia/reperfusion injury by promoting CD4(+)CD25(+)FOXP3(+) treg cell differentiation
por: Tang, Shengjie, et al.
Publicado: (2023)

Adoptive Transfers of CD4(+)CD25(+) Tregs Raise Foxp3 Expression and Alleviate Mouse Enteritis
por: Wang, Kai, et al.
Publicado: (2018)

Cationic domains in particle-forming and assembly-deficient HBV core antigens capture mammalian RNA that stimulates Th1-biased antibody responses by DNA vaccination
por: Krieger, Jana, et al.
Publicado: (2018)

Interplay of T Helper 17 Cells with CD4(+)CD25(high) FOXP3(+) Tregs in Regulation of Allergic Asthma in Pediatric Patients
por: Agarwal, Amit, et al.
Publicado: (2014)

Increased numbers of CD5(+)CD19(+)CD1d(high)IL-10(+) Bregs, CD4(+)Foxp3(+) Tregs, CD4(+)CXCR5(+)Foxp3(+) follicular regulatory T (TFR) cells in CHB or CHC patients
por: Wang, Li, et al.
Publicado: (2014)

In Vivo Dynamical Interactions between CD4 Tregs, CD8 Tregs and CD4(+)CD25(−) Cells in Mice
por: Arazi, Arnon, et al.
Publicado: (2009)

Circulating CD4(+) Treg, CD8(+) Treg, and CD3(+) γδ T Cell Subpopulations in Ovarian Cancer
por: Li, Rong, et al.
Publicado: (2023)

Human β-Cell Killing by Autoreactive Preproinsulin-Specific CD8 T Cells Is Predominantly Granule-Mediated With the Potency Dependent Upon T-Cell Receptor Avidity
por: Knight, Robin R., et al.
Publicado: (2013)

Homeostatic maintenance of natural Foxp3 (+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization
por: Setoguchi, Ruka, et al.
Publicado: (2005)

Increased CD4(+)CD45RA(-)FoxP3(low) cells alter the balance between Treg and Th17 cells in colitis mice
por: Ma, Ya-Hui, et al.
Publicado: (2016)

The correlation between infiltration of FoxP3(+) Tregs, CD66b(+) TANs and CD163(+) TAMs in colorectal cancer
por: Ren, Yuehan, et al.
Publicado: (2022)

Rapamycin relieves lupus nephritis by regulating TIM-3 and CD4(+)CD25(+)Foxp3(+) Treg cells in an MRL/lpr mouse model
por: Gao, Yan-fang, et al.
Publicado: (2022)

Relationship Between Infiltration of CD163(+) TAMs, FoxP3(+) Tregs, or CD66b(+) TANs and Cell Differentiation in Colorectal Cancer Tissues
por: Wang, Xiaobo, et al.
Publicado: (2023)

Human islet T cells are highly reactive to preproinsulin in type 1 diabetes
por: Anderson, Amanda M., et al.
Publicado: (2021)

Characteristics and PD-1 expression of peripheral CD4(+)CD127(lo)CD25(hi)FoxP3(+ )Treg cells in chronic HCV infected-patients
por: Shen, Tao, et al.
Publicado: (2011)

Sub-lethal ionizing radiation alters Foxp3 expression in CD4+ T regulatory (Treg) cells in vitro and in vivo
por: Kumari, Anita, et al.
Publicado: (2015)

Foxp3(+) Treg Cells Are Associated with Pathological Process of Autoimmune Hepatitis by Activating Methylation Modification in Autoimmune Hepatitis Patients
por: Chen, Jiang, et al.
Publicado: (2019)

Conversion of Peripheral CD4(+)CD25(−) Naive T Cells to CD4(+)CD25(+) Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3
por: Chen, WanJun, et al.
Publicado: (2003)

Evaluation of The Number of CD4(+) CD25(+) FoxP3(+) Treg Cells in Normal Mice Exposed to AFB(1) and Treated with Aged Garlic Extract
por: Larypoor, Mohaddeseh, et al.
Publicado: (2013)

IL-34 Actions on FOXP3(+) Tregs and CD14(+) Monocytes Control Human Graft Rejection
por: Bézie, Séverine, et al.
Publicado: (2020)

CD4(+)CD25(+)CD127(−) and CD4(+)CD25(+)Foxp3(+) Regulatory T Cell Subsets in Mediating Autoimmune Reactivity in Systemic Lupus Erythematosus Patients
por: Żabińska, Marcelina, et al.
Publicado: (2016)

CD4+CD25+CD127-Foxp3+ and CD8+CD28- Tregs in Renal Transplant Recipients: Phenotypic Patterns, Association With Immunosuppressive Drugs, and Interaction With Effector CD8+ T Cells and CD19+IL-10+ Bregs
por: Aly, Mostafa G., et al.
Publicado: (2021)

CCL11 increases the proportion of CD4(+)CD25(+)Foxp3(+) Treg cells and the production of IL-2 and TGF-β by CD4(+) T cells via the STAT5 signaling pathway
por: Wang, Rong, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_omqtr3ijtnj7mpc82qenq5m4uo