A sodium channel inhibitor ISTX-I with a novel structure provides a new hint at the evolutionary link between two toxin folds

Members of arachnida, such as spiders and scorpions, commonly produce venom with specialized venom glands, paralyzing their prey with neurotoxins that specifically target ion channels. Two well-studied motifs, the disulfide-directed hairpin (DDH) and the inhibitor cystine knot motif (ICK), are both...

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Detalles Bibliográficos
Autores principales: Rong, Mingqiang, Liu, Jiangxin, Zhang, Meilin, Wang, Gan, Zhao, Gang, Wang, Guodong, Zhang, Yaping, Hu, Kaifeng, Lai, Ren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942781/
https://www.ncbi.nlm.nih.gov/pubmed/27407029
http://dx.doi.org/10.1038/srep29691

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942781/
https://www.ncbi.nlm.nih.gov/pubmed/27407029
http://dx.doi.org/10.1038/srep29691

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