Tissue turnover of collagen type I, III and elastin is elevated in the PCLS model of IPF and can be restored back to vehicle levels using a phosphodiesterase inhibitor

BACKGROUND: The aim of this study was to develop and validate a model for pulmonary fibrosis, using ex vivo tissue cultures of lungs from bleomycin treated animals, enabling the investigation of fibrosis remodeling using novel biomarkers for the detection of ECM protein fragments. The combination of...

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Detalles Bibliográficos
Autores principales: Hansen, Niels Ulrik Brandt, Karsdal, Morten Asser, Brockbank, Sarah, Cruwys, Simon, Rønnow, Sarah, Leeming, Diana Julie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942917/
https://www.ncbi.nlm.nih.gov/pubmed/27411390
http://dx.doi.org/10.1186/s12931-016-0394-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942917/
https://www.ncbi.nlm.nih.gov/pubmed/27411390
http://dx.doi.org/10.1186/s12931-016-0394-8

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