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Tissue turnover of collagen type I, III and elastin is elevated in the PCLS model of IPF and can be restored back to vehicle levels using a phosphodiesterase inhibitor
BACKGROUND: The aim of this study was to develop and validate a model for pulmonary fibrosis, using ex vivo tissue cultures of lungs from bleomycin treated animals, enabling the investigation of fibrosis remodeling using novel biomarkers for the detection of ECM protein fragments. The combination of...
Autores principales: | Hansen, Niels Ulrik Brandt, Karsdal, Morten Asser, Brockbank, Sarah, Cruwys, Simon, Rønnow, Sarah, Leeming, Diana Julie |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942917/ https://www.ncbi.nlm.nih.gov/pubmed/27411390 http://dx.doi.org/10.1186/s12931-016-0394-8 |
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