Silibinin induces mitochondrial NOX4-mediated endoplasmic reticulum stress response and its subsequent apoptosis

BACKGROUND: Silibinin, a biologically active compound of milk thistle, has chemopreventive effects on cancer cell lines. Recently it was reported that silibinin inhibited tumor growth through activation of the apoptotic signaling pathway. Although various evidences showed multiple signaling pathways...

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Detalles Bibliográficos
Autores principales: Kim, Sang-Hun, Kim, Kwang-Youn, Yu, Sun-Nyoung, Seo, Young-Kyo, Chun, Sung-Sik, Yu, Hak-Sun, Ahn, Soon-Cheol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942927/
https://www.ncbi.nlm.nih.gov/pubmed/27405931
http://dx.doi.org/10.1186/s12885-016-2516-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942927/
https://www.ncbi.nlm.nih.gov/pubmed/27405931
http://dx.doi.org/10.1186/s12885-016-2516-6

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