Cargando…
A Theoretical Lower Bound for Selection on the Expression Levels of Proteins
We use simple models of the costs and benefits of microbial gene expression to show that changing a protein’s expression away from its optimum by 2-fold should reduce fitness by at least [Formula: see text] , where P is the fraction the cell’s protein that the gene accounts for. As microbial genes a...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2016
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943197/ https://www.ncbi.nlm.nih.gov/pubmed/27289091 http://dx.doi.org/10.1093/gbe/evw126 |