Cargando…

A Quantitative Analysis of Complexity of Human Pathogen-Specific CD4 T Cell Responses in Healthy M. tuberculosis Infected South Africans

We performed a quantitative analysis of the HLA restriction, antigen and epitope specificity of human pathogen specific responses in healthy individuals infected with M. tuberculosis (Mtb), in a South African cohort as a test case. The results estimate the breadth of T cell responses for the first t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lindestam Arlehamn, Cecilia S., McKinney, Denise M., Carpenter, Chelsea, Paul, Sinu, Rozot, Virginie, Makgotlho, Edward, Gregg, Yolande, van Rooyen, Michele, Ernst, Joel D., Hatherill, Mark, Hanekom, Willem A., Peters, Bjoern, Scriba, Thomas J., Sette, Alessandro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943605/ https://www.ncbi.nlm.nih.gov/pubmed/27409590 http://dx.doi.org/10.1371/journal.ppat.1005760

Ejemplares similares

Expression of specific HLA class II alleles is associated with an increased risk for active tuberculosis and a distinct gene expression profile
por: Chihab, Leila Y., et al.
Publicado: (2022)

Experimental validation of the RATE tool for inferring HLA restrictions of T cell epitopes
por: Paul, Sinu, et al.
Publicado: (2017)

Lack of evidence for BCG vaccine protection from severe COVID-19
por: Lindestam Arlehamn, Cecilia S., et al.
Publicado: (2020)

Automatic Generation of Validated Specific Epitope Sets
por: Carrasco Pro, Sebastian, et al.
Publicado: (2015)

Definition of CD4 Immunosignatures Associated with MTB
por: Lindestam Arlehamn, Cecilia S., et al.
Publicado: (2014)

A Review on T Cell Epitopes Identified Using Prediction and Cell-Mediated Immune Models for Mycobacterium tuberculosis and Bordetella pertussis
por: Tian, Yuan, et al.
Publicado: (2018)

Host Transcriptomics as a Tool to Identify Diagnostic and Mechanistic Immune Signatures of Tuberculosis
por: Burel, Julie G., et al.
Publicado: (2019)

The Challenge of Distinguishing Cell–Cell Complexes from Singlet Cells in Non‐Imaging Flow Cytometry and Single‐Cell Sorting
por: Burel, Julie G., et al.
Publicado: (2020)

Microbiota epitope similarity either dampens or enhances the immunogenicity of disease-associated antigenic epitopes
por: Carrasco Pro, Sebastian, et al.
Publicado: (2018)

Memory T Cells in Latent Mycobacterium tuberculosis Infection Are Directed against Three Antigenic Islands and Largely Contained in a CXCR3(+)CCR6(+) Th1 Subset
por: Lindestam Arlehamn, Cecilia S., et al.
Publicado: (2013)

A comparison of antigen-specific T cell responses induced by six novel tuberculosis vaccine candidates
por: Rodo, Miguel J., et al.
Publicado: (2019)

Autoimmunity in Parkinson's Disease: The Role of α-Synuclein-Specific T Cells
por: Garretti, Francesca, et al.
Publicado: (2019)

Central and Peripheral Inflammation: Connecting the Immune Responses of Parkinson’s Disease
por: Williams, Gregory P., et al.
Publicado: (2022)

Definition of Human Epitopes Recognized in Tetanus Toxoid and Development of an Assay Strategy to Detect Ex Vivo Tetanus CD4(+) T Cell Responses
por: da Silva Antunes, Ricardo, et al.
Publicado: (2017)

Correction: Definition of Human Epitopes Recognized in Tetanus Toxoid and Development of an Assay Strategy to Detect Ex Vivo Tetanus CD4(+) T Cell Responses
por: da Silva Antunes, Ricardo, et al.
Publicado: (2018)

Classical CD4 T cells as the cornerstone of antimycobacterial immunity
por: Morgan, Jeffrey, et al.
Publicado: (2021)

Pseudomonas aeruginosa pilin activates the inflammasome
por: Lindestam Arlehamn, Cecilia S, et al.
Publicado: (2011)

The Role of Potassium in Inflammasome Activation by Bacteria
por: Arlehamn, Cecilia S. Lindestam, et al.
Publicado: (2010)

Major Histocompatibility Complex Binding, Eluted Ligands, and Immunogenicity: Benchmark Testing and Predictions
por: Paul, Sinu, et al.
Publicado: (2020)

Immune profiling of Mycobacterium tuberculosis-specific T cells in recent and remote infection
por: Mpande, Cheleka A.M., et al.
Publicado: (2021)

Limited recognition of Mycobacterium tuberculosis-infected macrophages by polyclonal CD4 and CD8 T cells from the lungs of infected mice
por: Patankar, Yash R., et al.
Publicado: (2019)

Quantitative and Qualitative Perturbations of CD8(+) MAITs in Healthy Mycobacterium tuberculosis–Infected Individuals
por: Pomaznoy, Mikhail, et al.
Publicado: (2020)

T Cell Responses to Neural Autoantigens Are Similar in Alzheimer’s Disease Patients and Age-Matched Healthy Controls
por: Dhanwani, Rekha, et al.
Publicado: (2020)

Corrigendum: T Cell Responses to Neural Autoantigens Are Similar in Alzheimer's Disease Patients and Age-Matched Healthy Controls
por: Dhanwani, Rekha, et al.
Publicado: (2021)

Allele-Specific Thresholds of Eluted Ligands for T-Cell Epitope Prediction
por: Reardon, Brian, et al.
Publicado: (2021)

T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection
por: Musvosvi, Munyaradzi, et al.
Publicado: (2023)

The TCR repertoire of α-synuclein-specific T cells in Parkinson’s disease is surprisingly diverse
por: Singhania, Akul, et al.
Publicado: (2021)

CD4+CCR6+ T cells dominate the BCG-induced transcriptional signature
por: Singhania, Akul, et al.
Publicado: (2021)

Editorial: Exploring Immune Variability in Susceptibility to Tuberculosis Infection in Humans
por: Seshadri, Chetan, et al.
Publicado: (2022)

Multidimensional analysis of immune responses identified biomarkers of recent Mycobacterium tuberculosis infection
por: Lloyd, Tessa, et al.
Publicado: (2021)

Anti-HIV potency of T-cell responses elicited by dendritic cell therapeutic vaccination
por: Surenaud, Mathieu, et al.
Publicado: (2019)

Mycobacterium tuberculosis-specific CD4 T cells expressing CD153 inversely associate with bacterial load and disease severity in human tuberculosis
por: Du Bruyn, Elsa, et al.
Publicado: (2020)

Imprinting of Gut-Homing Receptors on Mtb-Specific Th1* Cells Is Associated with Reduced Lung Homing after Gavage BCG Vaccination of Rhesus Macaques
por: Hoft, Stella G., et al.
Publicado: (2023)

Effects of MVA85A vaccine on tuberculosis challenge in animals: systematic review
por: McShane, Helen, et al.
Publicado: (2016)

Efficacy of percutaneous versus intradermal BCG in the prevention of tuberculosis in South African infants: randomised trial
por: Hawkridge, Anthony, et al.
Publicado: (2008)

Disease extent and anti‐tubercular treatment response correlates with Mycobacterium tuberculosis‐specific CD4 T‐cell phenotype regardless of HIV‐1 status
por: Riou, Catherine, et al.
Publicado: (2020)

The Immune Epitope Database and Analysis Resource in Epitope Discovery and Synthetic Vaccine Design
por: Fleri, Ward, et al.
Publicado: (2017)

Application of a whole blood mycobacterial growth inhibition assay to study immunity against Mycobacterium tuberculosis in a high tuberculosis burden population
por: Baguma, Richard, et al.
Publicado: (2017)

Combined Use of Mycobacterium tuberculosis–Specific CD4 and CD8 T-Cell Responses Is a Powerful Diagnostic Tool of Active Tuberculosis
por: Rozot, Virginie, et al.
Publicado: (2015)

α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease
por: Lindestam Arlehamn, Cecilia S., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_2v1g370n9sa73s65ea5s0fp13u