Tissue Kallikrein Alleviates Cerebral Ischemia-Reperfusion Injury by Activating the B2R-ERK1/2-CREB-Bcl-2 Signaling Pathway in Diabetic Rats

Diabetes mellitus (DM) substantially increases the risk of ischemic stroke and reduces the tolerance to ischemic insults. Tissue kallikrein (TK) has been demonstrated to protect neurons from ischemia/reperfusion (I/R) injury in orthoglycemic model by activating the bradykinin B2 receptor (B2R). Cons...

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Detalles Bibliográficos
Autores principales: Shi, Ruifeng, Yuan, Kunxiong, Hu, Bin, Sang, Hongfei, Zhou, Lizhi, Xie, Yi, Xu, Lili, Cao, Qinqin, Chen, Xin, Zhao, Lingling, Xiong, Yunyun, Xu, Gelin, Liu, Xinfeng, Liu, Ling, Zhang, Renliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944080/
https://www.ncbi.nlm.nih.gov/pubmed/27446506
http://dx.doi.org/10.1155/2016/1843201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944080/
https://www.ncbi.nlm.nih.gov/pubmed/27446506
http://dx.doi.org/10.1155/2016/1843201

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