Cargando…

Tissue Kallikrein Alleviates Cerebral Ischemia-Reperfusion Injury by Activating the B2R-ERK1/2-CREB-Bcl-2 Signaling Pathway in Diabetic Rats

Diabetes mellitus (DM) substantially increases the risk of ischemic stroke and reduces the tolerance to ischemic insults. Tissue kallikrein (TK) has been demonstrated to protect neurons from ischemia/reperfusion (I/R) injury in orthoglycemic model by activating the bradykinin B2 receptor (B2R). Cons...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shi, Ruifeng, Yuan, Kunxiong, Hu, Bin, Sang, Hongfei, Zhou, Lizhi, Xie, Yi, Xu, Lili, Cao, Qinqin, Chen, Xin, Zhao, Lingling, Xiong, Yunyun, Xu, Gelin, Liu, Xinfeng, Liu, Ling, Zhang, Renliang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944080/ https://www.ncbi.nlm.nih.gov/pubmed/27446506 http://dx.doi.org/10.1155/2016/1843201

Ejemplares similares

Tissue Kallikrein Prevents Restenosis After Stenting of Severe Atherosclerotic Stenosis of the Middle Cerebral Artery: A Randomized Controlled Trial
por: Shi, Ruifeng, et al.
Publicado: (2016)

Artemisinin attenuated ischemic stroke induced cell apoptosis through activation of ERK1/2/CREB/BCL-2 signaling pathway in vitro and in vivo
por: Peng, Tangming, et al.
Publicado: (2022)

The effect of socioeconomic status on three-year mortality after first-ever ischemic stroke in Nanjing, China
por: Zhou, Guangyi, et al.
Publicado: (2006)

Activation of the ERK/Creb/Bcl-2 pathway protects periodontal ligament stem cells against hydrogen peroxide-induced oxidative stress
por: Fu, Xiaohui, et al.
Publicado: (2019)

Tilianin Reduces Apoptosis via the ERK/EGR1/BCL2L1 Pathway in Ischemia/Reperfusion-Induced Acute Kidney Injury Mice
por: Liu, Zengying, et al.
Publicado: (2022)

The combination of Astragalus membranaceus and ligustrazine mitigates cerebral ischemia‐reperfusion injury via regulating NR2B‐ERK/CREB signaling
por: Tang, Xialing, et al.
Publicado: (2022)

BC094916 suppressed SP 2/0 xenograft tumor by down-regulating Creb1 and Bcl2 transcription
por: Xu, Ruonan, et al.
Publicado: (2018)

Sulforaphene induces apoptosis and inhibits the invasion of esophageal cancer cells through MSK2/CREB/Bcl-2 and cadherin pathway in vivo and in vitro
por: Zhang, Chengjuan, et al.
Publicado: (2019)

TRPC channel-mediated neuroprotection by PDGF involves Pyk2/ERK/CREB pathway
por: Yao, Honghong, et al.
Publicado: (2009)

Breast cancer susceptibility protein 1 (BRCA1) rescues neurons from cerebral ischemia/reperfusion injury through NRF2-mediated antioxidant pathway
por: Xu, Pengfei, et al.
Publicado: (2018)

β‑adrenergic receptor activation promotes the proliferation of HepG2 cells via the ERK1/2/CREB pathways
por: Lin, Xingcheng, et al.
Publicado: (2023)

Mechanism of ERK/CREB pathway in pain and analgesia
por: Zhen, Weizhe, et al.
Publicado: (2023)

Endothelial caveolin-1 regulates cerebral thrombo-inflammation in acute ischemia/reperfusion injury
por: Zhang, Xiaohao, et al.
Publicado: (2022)

Developmental iodine deficiency resulting in hypothyroidism reduces hippocampal ERK1/2 and CREB in lactational and adolescent rats
por: Dong, Jing, et al.
Publicado: (2009)

Direct Targeting of CREB1 with Imperatorin Inhibits TGFβ2‐ERK Signaling to Suppress Esophageal Cancer Metastasis
por: Xu, Wen Wen, et al.
Publicado: (2020)

Dopaminergic control of ADAMTS2 expression through cAMP/CREB and ERK: molecular effects of antipsychotics
por: Ruso-Julve, Fulgencio, et al.
Publicado: (2019)

Fluorine‐incorporated TiO(2) nanotopography enhances adhesion and differentiation through ERK/CREB pathway
por: Ro, Hyang‐Seon, et al.
Publicado: (2020)

Resveratrol induces apoptosis in human melanoma cell through negatively regulating Erk/PKM2/Bcl-2 axis
por: Zhao, Hailong, et al.
Publicado: (2018)

Hypertension unawareness among Chinese patients with first-ever stroke
por: Cao, Qinqin, et al.
Publicado: (2016)

Protective effect of gastrodin on myocardial ischemia-reperfusion injury and the expression of Bax and Bcl-2
por: Han, Xiao, et al.
Publicado: (2019)

MicroRNA-365 alleviates morphine analgesic tolerance via the inactivation of the ERK/CREB signaling pathway by negatively targeting β-arrestin2
por: Wu, Xian-Ping, et al.
Publicado: (2018)

HUMAN PLASMA ALPHA 2-MACROGLOBULIN : AN INHIBITOR OF PLASMA KALLIKREIN
por: Harpel, Peter C.
Publicado: (1970)

Desmoglein 2 is a substrate of kallikrein 7 in pancreatic cancer
por: Ramani, Vishnu C, et al.
Publicado: (2008)

Down Syndrome Critical Region 1 Reduces Oxidative Stress–Induced Retinal Ganglion Cells Apoptosis via CREB–Bcl-2 Pathway
por: Shi, Yuxun, et al.
Publicado: (2020)

Electroacupuncture alleviates cerebral ischemia and reperfusion injury via modulation of the ERK1/2 signaling pathway
por: Jin, Xiao-lu, et al.
Publicado: (2016)

Nuclear respiratory factor 1 drives hepatocellular carcinoma progression by activating LPCAT1-ERK1/2-CREB axis
por: Liu, Ran, et al.
Publicado: (2023)

Laser Acupuncture Exerts Neuroprotective Effects via Regulation of Creb, Bdnf, Bcl-2, and Bax Gene Expressions in the Hippocampus
por: Yun, Yeong-Chan, et al.
Publicado: (2017)

p53 regulates ERK1/2/CREB cascade via a novel SASH1/MAP2K2 crosstalk to induce hyperpigmentation
por: Zhou, Ding'an, et al.
Publicado: (2017)

Noxa upregulation by oncogenic activation of MEK/ERK through CREB promotes autophagy in human melanoma cells
por: Liu, Yi Lun, et al.
Publicado: (2014)

Ginsenoside Rb1 attenuates methamphetamine (METH)-induced neurotoxicity through the NR2B/ERK/CREB/BDNF signalings in vitro and in vivo models
por: Yang, Genmeng, et al.
Publicado: (2022)

BCL2-regulated apoptotic process in myocardial ischemia-reperfusion injury (Review)
por: Korshunova, Anna Yu., et al.
Publicado: (2021)

Inhibition of ERK1/2 Worsens Intestinal Ischemia/Reperfusion Injury
por: Ban, Kechen, et al.
Publicado: (2013)

Tyrosol Prevents Ischemia/Reperfusion-Induced Cardiac Injury in H9c2 Cells: Involvement of ROS, Hsp70, JNK and ERK, and Apoptosis
por: Sun, Liwei, et al.
Publicado: (2015)

Radioimmunotherapy of prostate cancer targeting human kallikrein-related peptidase 2
por: Vilhelmsson Timmermand, O., et al.
Publicado: (2016)

NSFC Health Research Funding and Burden of Disease in China
por: Xu, Gelin, et al.
Publicado: (2014)

Artemether confers neuroprotection on cerebral ischemic injury through stimulation of the Erk1/2-P90rsk-CREB signaling pathway
por: Li, Shuai, et al.
Publicado: (2021)

Lower Serum Caveolin-1 Is Associated with Cerebral Microbleeds in Patients with Acute Ischemic Stroke
por: Zhang, Jun, et al.
Publicado: (2016)

Pharmacological effects of recombinant human tissue kallikrein on bradykinin B(2) receptors
por: Charest-Morin, Xavier, et al.
Publicado: (2015)

Involvement of kallikrein‐PAR2‐proinflammatory pathway in severe trastuzumab‐induced cardiotoxicity
por: Sasaki, Ritsuko, et al.
Publicado: (2022)

ROR2 increases the chemoresistance of melanoma by regulating p53 and Bcl2-family proteins via ERK hyperactivation
por: Castro, María Victoria, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_t1srrojf5sk5sg8r05ijqru1ih