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Tissue Kallikrein Alleviates Cerebral Ischemia-Reperfusion Injury by Activating the B2R-ERK1/2-CREB-Bcl-2 Signaling Pathway in Diabetic Rats
Diabetes mellitus (DM) substantially increases the risk of ischemic stroke and reduces the tolerance to ischemic insults. Tissue kallikrein (TK) has been demonstrated to protect neurons from ischemia/reperfusion (I/R) injury in orthoglycemic model by activating the bradykinin B2 receptor (B2R). Cons...
Autores principales: | Shi, Ruifeng, Yuan, Kunxiong, Hu, Bin, Sang, Hongfei, Zhou, Lizhi, Xie, Yi, Xu, Lili, Cao, Qinqin, Chen, Xin, Zhao, Lingling, Xiong, Yunyun, Xu, Gelin, Liu, Xinfeng, Liu, Ling, Zhang, Renliang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944080/ https://www.ncbi.nlm.nih.gov/pubmed/27446506 http://dx.doi.org/10.1155/2016/1843201 |
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