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G-protein-coupled receptor kinase 2 terminates G-protein-coupled receptor function in steroid hormone 20-hydroxyecdysone signaling

G-protein-coupled receptors (GPCRs) transmit extracellular signals across the cell membrane. GPCR kinases (GRKs) desensitize GPCR signals in the cell membrane. However, the role and mechanism of GRKs in the desensitization of steroid hormone signaling are unclear. In this study, we propose that GRK2...

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Detalles Bibliográficos
Autores principales: Zhao, Wen-Li, Wang, Di, Liu, Chun-Yan, Zhao, Xiao-Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944123/
https://www.ncbi.nlm.nih.gov/pubmed/27412951
http://dx.doi.org/10.1038/srep29205