ROCK1 reduces mitochondrial content and irisin production in muscle suppressing adipocyte browning and impairing insulin sensitivity

Irisin reportedly promotes the conversion of preadipocytes into “brown-like” adipocytes within subcutaneous white adipose tissue (WAT) via a mechanism that stimulates UCP-1 expression. An increase in plasma irisin has been associated with improved obesity and insulin resistance in mice with type 2 d...

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Detalles Bibliográficos
Autores principales: Zhou, Xiaoshuang, Li, Rongshan, Liu, Xinyan, Wang, Lihua, Hui, Peng, Chan, Lawrence, Saha, Pradip K., Hu, Zhaoyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944137/
https://www.ncbi.nlm.nih.gov/pubmed/27411515
http://dx.doi.org/10.1038/srep29669

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944137/
https://www.ncbi.nlm.nih.gov/pubmed/27411515
http://dx.doi.org/10.1038/srep29669

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