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Uncovering the Relationship between Sulphation Patterns and Conformation of Iduronic Acid in Heparan Sulphate

The L-iduronic acid (IdoA) residue is a critically important structural component in heparan sulphate polysaccharide for the biological functions. The pyranose ring of IdoA is present in (1)C(4)-chair, (2)S(O)-skew boat, and less frequently, in (4)C(1)-chair conformations. Here, we analyzed the conf...

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Detalles Bibliográficos
Autores principales: Hsieh, Po-Hung, Thieker, David F., Guerrini, Marco, Woods, Robert J., Liu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944151/
https://www.ncbi.nlm.nih.gov/pubmed/27412370
http://dx.doi.org/10.1038/srep29602