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AP-1/σ1A and AP-1/σ1B adaptor-proteins differentially regulate neuronal early endosome maturation via the Rab5/Vps34-pathway

The σ1 subunit of the AP-1 clathrin-coated-vesicle adaptor-protein complex is expressed as three isoforms. Tissues express σ1A and one of the σ1B and σ1C isoforms. Brain is the tissue with the highest σ1A and σ1B expression. σ1B-deficiency leads to severe mental retardation, accumulation of early en...

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Detalles Bibliográficos
Autores principales: Candiello, Ermes, Kratzke, Manuel, Wenzel, Dirk, Cassel, Dan, Schu, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944158/
https://www.ncbi.nlm.nih.gov/pubmed/27411398
http://dx.doi.org/10.1038/srep29950