Oncogenic KRAS triggers MAPK-dependent errors in mitosis and MYC-dependent sensitivity to anti-mitotic agents

Oncogenic KRAS induces cell proliferation and transformation, but little is known about its effects on cell division. Functional genetic screens have recently revealed that cancer cell lines expressing oncogenic KRAS are sensitive to interference with mitosis, but neither the mechanism nor the unifo...

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Detalles Bibliográficos
Autores principales: Perera, David, Venkitaraman, Ashok R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944194/
https://www.ncbi.nlm.nih.gov/pubmed/27412232
http://dx.doi.org/10.1038/srep29741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944194/
https://www.ncbi.nlm.nih.gov/pubmed/27412232
http://dx.doi.org/10.1038/srep29741

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