Modulation of B-cell receptor and microenvironment signaling by a guanine exchange factor in B-cell malignancies

Objective: Chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) cells over-express a guanine exchange factor (GEF), Rasgrf-1. This GEF increases active Ras as it catalyzes the removal of GDP from Ras so that GTP can bind and activate Ras. This study aims to study the mechanism of action...

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Detalles Bibliográficos
Autores principales: Liao, Wei, Sharma, Sanjai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Anti-Cancer Association 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944547/
https://www.ncbi.nlm.nih.gov/pubmed/27458535
http://dx.doi.org/10.20892/j.issn.2095-3941.2016.0026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944547/
https://www.ncbi.nlm.nih.gov/pubmed/27458535
http://dx.doi.org/10.20892/j.issn.2095-3941.2016.0026

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