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Modulation of B-cell receptor and microenvironment signaling by a guanine exchange factor in B-cell malignancies
Objective: Chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) cells over-express a guanine exchange factor (GEF), Rasgrf-1. This GEF increases active Ras as it catalyzes the removal of GDP from Ras so that GTP can bind and activate Ras. This study aims to study the mechanism of action...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Chinese Anti-Cancer Association
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944547/ https://www.ncbi.nlm.nih.gov/pubmed/27458535 http://dx.doi.org/10.20892/j.issn.2095-3941.2016.0026 |