The real role of pseudokinase: linking diabetes to cancers

A recent paper in Nature Communications shows that pseudokinase TRIB3 has a critical role in the development of diabetes‐related cancers via interacting with SQSTM1, a selective autophagy receptor. Interrupting the TRIB3‐SQSTM1 interaction using an α‐helix peptide shows a significant antitumor effec...

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Detalles Bibliográficos
Autores principales: Li, Ke, Hu, Zhuowei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944892/
https://www.ncbi.nlm.nih.gov/pubmed/27038142
http://dx.doi.org/10.1002/cam4.706
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author Li, Ke
Hu, Zhuowei
author_facet Li, Ke
Hu, Zhuowei
author_sort Li, Ke
collection PubMed
description A recent paper in Nature Communications shows that pseudokinase TRIB3 has a critical role in the development of diabetes‐related cancers via interacting with SQSTM1, a selective autophagy receptor. Interrupting the TRIB3‐SQSTM1 interaction using an α‐helix peptide shows a significant antitumor effect both in normal and diabetic mice. This work provides a potential strategy against cancers in patients with diabetes.
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spelling pubmed-49448922016-07-25 The real role of pseudokinase: linking diabetes to cancers Li, Ke Hu, Zhuowei Cancer Med Commentary A recent paper in Nature Communications shows that pseudokinase TRIB3 has a critical role in the development of diabetes‐related cancers via interacting with SQSTM1, a selective autophagy receptor. Interrupting the TRIB3‐SQSTM1 interaction using an α‐helix peptide shows a significant antitumor effect both in normal and diabetic mice. This work provides a potential strategy against cancers in patients with diabetes. John Wiley and Sons Inc. 2016-03-31 /pmc/articles/PMC4944892/ /pubmed/27038142 http://dx.doi.org/10.1002/cam4.706 Text en © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Li, Ke
Hu, Zhuowei
The real role of pseudokinase: linking diabetes to cancers
title The real role of pseudokinase: linking diabetes to cancers
title_full The real role of pseudokinase: linking diabetes to cancers
title_fullStr The real role of pseudokinase: linking diabetes to cancers
title_full_unstemmed The real role of pseudokinase: linking diabetes to cancers
title_short The real role of pseudokinase: linking diabetes to cancers
title_sort real role of pseudokinase: linking diabetes to cancers
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944892/
https://www.ncbi.nlm.nih.gov/pubmed/27038142
http://dx.doi.org/10.1002/cam4.706
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