Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection

The rate at which HIV-1 infected individuals progress to AIDS is highly variable and impacted by T cell immunity. CD8 T cell inhibitory molecules are up-regulated in HIV-1 infection and associate with immune dysfunction. We evaluated participants (n = 122) recruited to the SPARTAC randomised clinica...

Descripción completa

Detalles Bibliográficos
Autores principales: Hoffmann, Matthias, Pantazis, Nikos, Martin, Genevieve E., Hickling, Stephen, Hurst, Jacob, Meyerowitz, Jodi, Willberg, Christian B., Robinson, Nicola, Brown, Helen, Fisher, Martin, Kinloch, Sabine, Babiker, Abdel, Weber, Jonathan, Nwokolo, Nneka, Fox, Julie, Fidler, Sarah, Phillips, Rodney, Frater, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945085/
https://www.ncbi.nlm.nih.gov/pubmed/27415828
http://dx.doi.org/10.1371/journal.ppat.1005661

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945085/
https://www.ncbi.nlm.nih.gov/pubmed/27415828
http://dx.doi.org/10.1371/journal.ppat.1005661

Ejemplares similares