A Single Nucleotide Polymorphism in the Il17ra Promoter Is Associated with Functional Severity of Ankylosing Spondylitis

The aim of this study was to identify new genetic variants associated with the severity of ankylosing spondylitis (AS). We sequenced the exome of eight patients diagnosed with AS, selected on the basis of the severity of their clinical parameters. We identified 27 variants in exons and regulatory re...

Descripción completa

Detalles Bibliográficos
Autores principales: Vidal-Castiñeira, Jose Ramón, López-Vázquez, Antonio, Diaz-Peña, Roberto, Diaz-Bulnes, Paula, Martinez-Camblor, Pablo, Coto, Eliecer, Coto-Segura, Pablo, Bruges-Armas, Jacome, Pinto, Jose Antonio, Blanco, Francisco Jose, Sánchez, Alejandra, Mulero, Juan, Queiro, Ruben, Lopez-Larrea, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945092/
https://www.ncbi.nlm.nih.gov/pubmed/27415816
http://dx.doi.org/10.1371/journal.pone.0158905

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945092/
https://www.ncbi.nlm.nih.gov/pubmed/27415816
http://dx.doi.org/10.1371/journal.pone.0158905

Ejemplares similares