A CRISPR screen defines a signal peptide processing pathway required by flaviviruses

Flaviviruses infect hundreds of millions of people annually, with no antiviral therapy available(1,2). We performed a genome-wide CRISPR/Cas9-based screen to identify host genes that when edited resulted in reduced flavivirus infection. We validated nine human genes required for flavivirus infectivi...

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Detalles Bibliográficos
Autores principales: Zhang, Rong, Miner, Jonathan J., Gorman, Matthew J., Rausch, Keiko, Ramage, Holly, White, James P., Zuiani, Adam, Zhang, Ping, Fernandez, Estefania, Zhang, Qiang, Dowd, Kimberly A., Pierson, Theodore C., Cherry, Sara, Diamond, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945490/
https://www.ncbi.nlm.nih.gov/pubmed/27383988
http://dx.doi.org/10.1038/nature18625

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945490/
https://www.ncbi.nlm.nih.gov/pubmed/27383988
http://dx.doi.org/10.1038/nature18625

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