Improvement of gemcitabine sensitivity of p53-mutated pancreatic cancer MiaPaCa-2 cells by RUNX2 depletion-mediated augmentation of TAp73-dependent cell death

Pancreatic cancer exhibits the worst prognostic outcome among human cancers. Recently, we have described that depletion of RUNX2 enhances gemcitabine (GEM) sensitivity of p53-deficient pancreatic cancer AsPC-1 cells through the activation of TAp63-mediated cell death pathway. These findings raised a...

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Detalles Bibliográficos
Autores principales: Nakamura, M, Sugimoto, H, Ogata, T, Hiraoka, K, Yoda, H, Sang, M, Zhu, Y, Yu, M, Shimozato, O, Ozaki, T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945741/
https://www.ncbi.nlm.nih.gov/pubmed/27294865
http://dx.doi.org/10.1038/oncsis.2016.40

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945741/
https://www.ncbi.nlm.nih.gov/pubmed/27294865
http://dx.doi.org/10.1038/oncsis.2016.40

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