Ric-8A gene deletion or phorbol ester suppresses tumorigenesis in a mouse model of GNAQ(Q209L)-driven melanoma

The heterotrimeric G protein α subunit oncogenes GNAQ or GNA11 carry Q209X or R183X activating mutations and are present with ~90% frequency in human uveal melanomas. Forced expression of GNAQ/11(Q209L) in melanocytes is sufficient to drive metastatic melanoma in immune-compromised mice. No known dr...

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Detalles Bibliográficos
Autores principales: Patel, B R, Tall, G G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945744/
https://www.ncbi.nlm.nih.gov/pubmed/27348266
http://dx.doi.org/10.1038/oncsis.2016.45

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945744/
https://www.ncbi.nlm.nih.gov/pubmed/27348266
http://dx.doi.org/10.1038/oncsis.2016.45

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