PTEN negatively regulates mTORC2 formation and signaling in grade IV glioma via Rictor hyperphosphorylation at Thr1135 and direct the mode of action of an mTORC1/2 inhibitor

To investigate the role of PTEN (phosphatase and tensin homolog) in mammalian target of rapamycin complex 2 (mTORC2) signaling in glioblastoma multiforme (GBM), we found higher activation of mTORC2 in PTEN(mu) cells, as evidenced by enhanced phosphorylation of mTOR (Ser2481), AKT (Ser473) and glycog...

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Detalles Bibliográficos
Autores principales: Bhattacharya, K, Maiti, S, Mandal, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945751/
https://www.ncbi.nlm.nih.gov/pubmed/27239959
http://dx.doi.org/10.1038/oncsis.2016.34

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945751/
https://www.ncbi.nlm.nih.gov/pubmed/27239959
http://dx.doi.org/10.1038/oncsis.2016.34

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