Regulation of H-Ras-driven MAPK signaling, transformation and tumorigenesis, but not PI3K signaling and tumor progression, by plasma membrane microdomains

In this study, we assessed the contributions of plasma membrane (PM) microdomain targeting to the functions of H-Ras and R-Ras. These paralogs have identical effector-binding regions, but variant C-terminal targeting domains (tDs) which are responsible for lateral microdomain distribution: activated...

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Detalles Bibliográficos
Autores principales: Michael, J V, Wurtzel, J G T, Goldfinger, L E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945753/
https://www.ncbi.nlm.nih.gov/pubmed/27239960
http://dx.doi.org/10.1038/oncsis.2016.36

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945753/
https://www.ncbi.nlm.nih.gov/pubmed/27239960
http://dx.doi.org/10.1038/oncsis.2016.36

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