N-alkylated isatins evade P-gp mediated efflux and retain potency in MDR cancer cell lines

The search for novel anticancer therapeutics with the ability to overcome multi-drug resistance (MDR) mechanisms is of high priority. A class of molecules that show potential in overcoming MDR are the N-alkylated isatins. In particular 5,7-dibromo-N-alkylisatins are potent microtubule destabilizing...

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Detalles Bibliográficos
Autores principales: Vine, Kara L., Belfiore, Lisa, Jones, Luke, Locke, Julie M., Wade, Samantha, Minaei, Elahe, Ranson, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945850/
https://www.ncbi.nlm.nih.gov/pubmed/27441242
http://dx.doi.org/10.1016/j.heliyon.2015.e00060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945850/
https://www.ncbi.nlm.nih.gov/pubmed/27441242
http://dx.doi.org/10.1016/j.heliyon.2015.e00060

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