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N-alkylated isatins evade P-gp mediated efflux and retain potency in MDR cancer cell lines
The search for novel anticancer therapeutics with the ability to overcome multi-drug resistance (MDR) mechanisms is of high priority. A class of molecules that show potential in overcoming MDR are the N-alkylated isatins. In particular 5,7-dibromo-N-alkylisatins are potent microtubule destabilizing...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945850/ https://www.ncbi.nlm.nih.gov/pubmed/27441242 http://dx.doi.org/10.1016/j.heliyon.2015.e00060 |