Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors

Human galectins are promising targets for cancer immunotherapeutic and fibrotic disease-related drugs. We report herein the binding interactions of three thio-digalactosides (TDGs) including TDG itself, TD139 (3,3’-deoxy-3,3’-bis-(4-[m-fluorophenyl]-1H-1,2,3-triazol-1-yl)-thio-digalactoside, recentl...

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Detalles Bibliográficos
Autores principales: Hsieh, Tung-Ju, Lin, Hsien-Ya, Tu, Zhijay, Lin, Ting-Chien, Wu, Shang-Chuen, Tseng, Yu-Yao, Liu, Fu-Tong, Hsu, Shang-Te Danny, Lin, Chun-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945863/
https://www.ncbi.nlm.nih.gov/pubmed/27416897
http://dx.doi.org/10.1038/srep29457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945863/
https://www.ncbi.nlm.nih.gov/pubmed/27416897
http://dx.doi.org/10.1038/srep29457

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