Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor

Rocaglamide A (RocA) typifies a class of protein synthesis inhibitors that selectively kill aneuploid tumor cells and repress translation of specific mRNAs(1-4). RocA targets eukaryotic initiation factor 4A (eIF4A), an ATP-dependent DEAD-box RNA helicase; its mRNA selectivity is proposed to reflect...

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Detalles Bibliográficos
Autores principales: Iwasaki, Shintaro, Floor, Stephen N., Ingolia, Nicholas T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946961/
https://www.ncbi.nlm.nih.gov/pubmed/27309803
http://dx.doi.org/10.1038/nature17978

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946961/
https://www.ncbi.nlm.nih.gov/pubmed/27309803
http://dx.doi.org/10.1038/nature17978

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