Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma

Poor prognosis in neuroblastoma is associated with genetic amplification of MYCN. MYCN is itself a target of let-7, a tumor suppressor family of microRNAs implicated in numerous cancers. LIN28B, an inhibitor of let-7 biogenesis, is overexpressed in neuroblastoma and has been reported to regulate MYC...

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Detalles Bibliográficos
Autores principales: Powers, John T, Tsanov, Kaloyan M, Pearson, Daniel S, Roels, Frederik, Spina, Catherine S, Ebright, Richard, Seligson, Marc, de Soysa, Yvanka, Cahan, Patrick, Theiβen, Jessica, Tu, Ho-Chou, Han, Areum, Kurek, Kyle C, LaPier, Grace S, Osborne, Jihan K, Ross, Samantha J, Cesana, Marcella, Collins, James J, Berthold, Frank, Daley, George Q
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947006/
https://www.ncbi.nlm.nih.gov/pubmed/27383785
http://dx.doi.org/10.1038/nature18632

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947006/
https://www.ncbi.nlm.nih.gov/pubmed/27383785
http://dx.doi.org/10.1038/nature18632

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