A comprehensive study of the genetic impact of rare variants in SORL1 in European early-onset Alzheimer’s disease

The sortilin-related receptor 1 (SORL1) gene has been associated with increased risk for Alzheimer’s disease (AD). Rare genetic variants in the SORL1 gene have also been implicated in autosomal dominant early-onset AD (EOAD). Here we report a large-scale investigation of the contribution of genetic...

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Detalles Bibliográficos
Autores principales: Verheijen, Jan, Van den Bossche, Tobi, van der Zee, Julie, Engelborghs, Sebastiaan, Sanchez-Valle, Raquel, Lladó, Albert, Graff, Caroline, Thonberg, Håkan, Pastor, Pau, Ortega-Cubero, Sara, Pastor, Maria A., Benussi, Luisa, Ghidoni, Roberta, Binetti, Giuliano, Clarimon, Jordi, Lleó, Alberto, Fortea, Juan, de Mendonça, Alexandre, Martins, Madalena, Grau-Rivera, Oriol, Gelpi, Ellen, Bettens, Karolien, Mateiu, Ligia, Dillen, Lubina, Cras, Patrick, De Deyn, Peter P., Van Broeckhoven, Christine, Sleegers, Kristel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947104/
https://www.ncbi.nlm.nih.gov/pubmed/27026413
http://dx.doi.org/10.1007/s00401-016-1566-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947104/
https://www.ncbi.nlm.nih.gov/pubmed/27026413
http://dx.doi.org/10.1007/s00401-016-1566-9

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