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Challenges in identifying cancer genes by analysis of exome sequencing data

Massively parallel sequencing has permitted an unprecedented examination of the cancer exome, leading to predictions that all genes important to cancer will soon be identified by genetic analysis of tumours. To examine this potential, here we evaluate the ability of state-of-the-art sequence analysi...

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Detalles Bibliográficos
Autores principales: Hofree, Matan, Carter, Hannah, Kreisberg, Jason F., Bandyopadhyay, Sourav, Mischel, Paul S., Friend, Stephen, Ideker, Trey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947162/
https://www.ncbi.nlm.nih.gov/pubmed/27417679
http://dx.doi.org/10.1038/ncomms12096