Decreased NK-cell tumour immunosurveillance consequent to JAK inhibition enhances metastasis in breast cancer models

The JAK/STAT pathway is an attractive target for breast cancer therapy due to its frequent activation, and clinical trials evaluating JAK inhibitors (JAKi) in advanced breast cancer are ongoing. Using patient biopsies and preclinical models of breast cancer, we demonstrate that the JAK/STAT pathway...

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Detalles Bibliográficos
Autores principales: Bottos, Alessia, Gotthardt, Dagmar, Gill, Jason W., Gattelli, Albana, Frei, Anna, Tzankov, Alexandar, Sexl, Veronika, Wodnar-Filipowicz, Aleksandra, Hynes, Nancy E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947169/
https://www.ncbi.nlm.nih.gov/pubmed/27406745
http://dx.doi.org/10.1038/ncomms12258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947169/
https://www.ncbi.nlm.nih.gov/pubmed/27406745
http://dx.doi.org/10.1038/ncomms12258

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