Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity

Plants produce an enormous array of biologically active metabolites, often with stereochemical variations on the same molecular scaffold. These changes in stereochemistry dramatically impact biological activity. Notably, the stereoisomers of the heteroyohimbine alkaloids show diverse pharmacological...

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Detalles Bibliográficos
Autores principales: Stavrinides, Anna, Tatsis, Evangelos C., Caputi, Lorenzo, Foureau, Emilien, Stevenson, Clare E. M., Lawson, David M., Courdavault, Vincent, O'Connor, Sarah E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947188/
https://www.ncbi.nlm.nih.gov/pubmed/27418042
http://dx.doi.org/10.1038/ncomms12116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947188/
https://www.ncbi.nlm.nih.gov/pubmed/27418042
http://dx.doi.org/10.1038/ncomms12116

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