Deleting both PHLPP1 and CANP1 rescues impairments in long-term potentiation and learning in both single knockout mice

Calpain-1 (CANP1) has been shown to play a critical role in synaptic plasticity and learning and memory, as its deletion in mice results in impairment in theta-burst stimulation- (TBS) induced LTP and various forms of learning and memory. Likewise, PHLPP1 (aka SCOP) has also been found to participat...

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Detalles Bibliográficos
Autores principales: Liu, Yan, Sun, Jiandong, Wang, Yubin, Lopez, Dulce, Tran, Jennifer, Bi, Xiaoning, Baudry, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947237/
https://www.ncbi.nlm.nih.gov/pubmed/27421891
http://dx.doi.org/10.1101/lm.042721.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947237/
https://www.ncbi.nlm.nih.gov/pubmed/27421891
http://dx.doi.org/10.1101/lm.042721.116

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