Inhibition of EZH2 via activation of SAPK/JNK and reduction of p65 and DNMT1 as a novel mechanism in inhibition of human lung cancer cells by polyphyllin I

BACKGROUND: Polyphyllin I (PPI), a bioactive phytochemical extracted from the Rhizoma of Paris polyphylla, has been reported to exhibit anti-cancer activity. However, the detailed mechanism underlying this remains to be elucidated. METHODS: Cell viability and cell cycle distribution were measured us...

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Detalles Bibliográficos
Autores principales: Li, Longmei, Wu, JingJing, Zheng, Fang, Tang, Qing, Wu, WanYin, Hann, Swei Sunny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947306/
https://www.ncbi.nlm.nih.gov/pubmed/27421653
http://dx.doi.org/10.1186/s13046-016-0388-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947306/
https://www.ncbi.nlm.nih.gov/pubmed/27421653
http://dx.doi.org/10.1186/s13046-016-0388-x

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