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Inhibition of EZH2 via activation of SAPK/JNK and reduction of p65 and DNMT1 as a novel mechanism in inhibition of human lung cancer cells by polyphyllin I

BACKGROUND: Polyphyllin I (PPI), a bioactive phytochemical extracted from the Rhizoma of Paris polyphylla, has been reported to exhibit anti-cancer activity. However, the detailed mechanism underlying this remains to be elucidated. METHODS: Cell viability and cell cycle distribution were measured us...

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Detalles Bibliográficos
Autores principales:	Li, Longmei, Wu, JingJing, Zheng, Fang, Tang, Qing, Wu, WanYin, Hann, Swei Sunny
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947306/ https://www.ncbi.nlm.nih.gov/pubmed/27421653 http://dx.doi.org/10.1186/s13046-016-0388-x

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