Quantitative In Vitro and In Vivo Evaluation of Intestinal and Blood-Brain Barrier Transport Kinetics of the Plant N-Alkylamide Pellitorine

Objective. To evaluate the gut mucosa and blood-brain barrier (BBB) pharmacokinetic permeability properties of the plant N-alkylamide pellitorine. Methods. Pure pellitorine and an Anacyclus pyrethrum extract were used to investigate the permeation of pellitorine through (1) a Caco-2 cell monolayer,...

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Detalles Bibliográficos
Autores principales: Veryser, Lieselotte, Bracke, Nathalie, Wynendaele, Evelien, Joshi, Tanmayee, Tatke, Pratima, Taevernier, Lien, De Spiegeleer, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947679/
https://www.ncbi.nlm.nih.gov/pubmed/27493960
http://dx.doi.org/10.1155/2016/5497402

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947679/
https://www.ncbi.nlm.nih.gov/pubmed/27493960
http://dx.doi.org/10.1155/2016/5497402

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