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Quantitative In Vitro and In Vivo Evaluation of Intestinal and Blood-Brain Barrier Transport Kinetics of the Plant N-Alkylamide Pellitorine

Objective. To evaluate the gut mucosa and blood-brain barrier (BBB) pharmacokinetic permeability properties of the plant N-alkylamide pellitorine. Methods. Pure pellitorine and an Anacyclus pyrethrum extract were used to investigate the permeation of pellitorine through (1) a Caco-2 cell monolayer,...

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Detalles Bibliográficos
Autores principales:	Veryser, Lieselotte, Bracke, Nathalie, Wynendaele, Evelien, Joshi, Tanmayee, Tatke, Pratima, Taevernier, Lien, De Spiegeleer, Bart
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947679/ https://www.ncbi.nlm.nih.gov/pubmed/27493960 http://dx.doi.org/10.1155/2016/5497402

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