Identification of genetic variants of LGI1 and RTN4R (NgR1) linked to schizophrenia that are defective in NgR1–LGI1 signaling

BACKGROUND: The protein NgR1 is encoded by RTN4R, a gene linked to schizophrenia. We previously reported NgR1 as receptor for the epilepsy‐linked protein LGI1. NgR1 regulates synapse number and synaptic plasticity, whereas LGI1 antagonizes NgR1 signaling and promotes synapse formation. Impairments i...

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Detalles Bibliográficos
Autores principales: Thomas, Rhalena A., Ambalavanan, Amirthagowri, Rouleau, Guy A., Barker, Philip A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947863/
https://www.ncbi.nlm.nih.gov/pubmed/27468420
http://dx.doi.org/10.1002/mgg3.215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947863/
https://www.ncbi.nlm.nih.gov/pubmed/27468420
http://dx.doi.org/10.1002/mgg3.215

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