Recombinant herpes simplex virus type 1 strains with targeted mutations relevant for aciclovir susceptibility

Here, we describe a novel reliable method to assess the significance of individual mutations within the thymidine kinase (TK) gene of herpes simplex virus type 1 (HSV-1) to nucleoside analogue resistance. Eleven defined single nucleotide polymorphisms that occur in the TK gene of clinical HSV-1 isol...

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Detalles Bibliográficos
Autores principales: Brunnemann, Anne-Kathrin, Liermann, Kristin, Deinhardt-Emmer, Stefanie, Maschkowitz, Gregor, Pohlmann, Anja, Sodeik, Beate, Fickenscher, Helmut, Sauerbrei, Andreas, Krumbholz, Andi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947914/
https://www.ncbi.nlm.nih.gov/pubmed/27426251
http://dx.doi.org/10.1038/srep29903

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947914/
https://www.ncbi.nlm.nih.gov/pubmed/27426251
http://dx.doi.org/10.1038/srep29903

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