LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts

Leucine-rich repeat kinase 2 (LRRK2) has been linked to several clinical disorders including Parkinson’s disease (PD), Crohn’s disease, and leprosy. Furthermore in rodents, LRRK2 deficiency or inhibition leads to lysosomal pathology in kidney and lung. Here we provide evidence that LRRK2 functions t...

Descripción completa

Detalles Bibliográficos
Autores principales: Kuwahara, Tomoki, Inoue, Keiichi, D’Agati, Vivette D., Fujimoto, Tetta, Eguchi, Tomoya, Saha, Shamol, Wolozin, Benjamin, Iwatsubo, Takeshi, Abeliovich, Asa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947924/
https://www.ncbi.nlm.nih.gov/pubmed/27424887
http://dx.doi.org/10.1038/srep29945

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947924/
https://www.ncbi.nlm.nih.gov/pubmed/27424887
http://dx.doi.org/10.1038/srep29945

Ejemplares similares