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LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts
Leucine-rich repeat kinase 2 (LRRK2) has been linked to several clinical disorders including Parkinson’s disease (PD), Crohn’s disease, and leprosy. Furthermore in rodents, LRRK2 deficiency or inhibition leads to lysosomal pathology in kidney and lung. Here we provide evidence that LRRK2 functions t...
Autores principales: | Kuwahara, Tomoki, Inoue, Keiichi, D’Agati, Vivette D., Fujimoto, Tetta, Eguchi, Tomoya, Saha, Shamol, Wolozin, Benjamin, Iwatsubo, Takeshi, Abeliovich, Asa |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947924/ https://www.ncbi.nlm.nih.gov/pubmed/27424887 http://dx.doi.org/10.1038/srep29945 |
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