Crosstalk between cystine and glutathione is critical for the regulation of amino acid signaling pathways and ferroptosis

Although essential amino acids regulate mechanistic target of rapamycin complex 1 (mTORC1) and the integrated stress response (ISR), the role of cysteine is unknown. We found that in hepatoma HepG2 cells, cystine (oxidized form of cysteine) activated mTORC1 and suppressed the ISR. Cystine deprivatio...

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Detalles Bibliográficos
Autores principales: Yu, Xinlei, Long, Yun Chau
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948025/
https://www.ncbi.nlm.nih.gov/pubmed/27425006
http://dx.doi.org/10.1038/srep30033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948025/
https://www.ncbi.nlm.nih.gov/pubmed/27425006
http://dx.doi.org/10.1038/srep30033

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