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Crosstalk between cystine and glutathione is critical for the regulation of amino acid signaling pathways and ferroptosis
Although essential amino acids regulate mechanistic target of rapamycin complex 1 (mTORC1) and the integrated stress response (ISR), the role of cysteine is unknown. We found that in hepatoma HepG2 cells, cystine (oxidized form of cysteine) activated mTORC1 and suppressed the ISR. Cystine deprivatio...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948025/ https://www.ncbi.nlm.nih.gov/pubmed/27425006 http://dx.doi.org/10.1038/srep30033 |