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Insight into the relationship between the cell culture model, cell trafficking and siRNA silencing efficiency

Despite research efforts, cell uptake processes determining siRNA silencing efficiency remain unclear. Here, we examine the relationship between in vitro cell culture models, cellular trafficking and siRNA silencing efficiency to provide a mechanistic insight on siRNA delivery system design. Model s...

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Detalles Bibliográficos
Autores principales: Capel, Victoria, Vllasaliu, Driton, Watts, Peter, Stolnik, Snow
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948577/
https://www.ncbi.nlm.nih.gov/pubmed/27349867
http://dx.doi.org/10.1016/j.bbrc.2016.06.054